In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with NPHS2 mutation
نویسندگان
چکیده
منابع مشابه
Hypoxia decreases podocyte expression of slit diaphragm proteins
BACKGROUND Chronic hypoxia contributes to progressive tubulointerstitial injury and, consequently, renal failure. However, the effect of hypoxia on glomerular podocytes, which are integral to the slit diaphragm complex and responsible for selectivity of the glomerular filtration barrier, has not been completely determined. METHODS Conditionally immortalized mouse podocyte cells were exposed t...
متن کاملBioinformatics evaluation of NPHS2 deletion mutation associated with congenital nephrotic syndrome in a consanguineous Pakistani family.
To the Editor, Congenital nephrotic syndrome (CNS) is an autosomal recessive, the most frequent and clinically heterogeneous renal disease. The disease is defined by childhood onset of heavy proteinuria, hypoalbuminemia, hyperlipidemia, edema, and minimal glomerular changes. Mutations of NPHS2 gene, encoding glomerular protein podocin are a major cause of autosomal-recessive steroid resistant n...
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چکیده ندارد.
15 صفحه اولEndocytic Trafficking at the Mature Podocyte Slit Diaphragm
Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently, cargo proteins can be delivered to lysosomes for degradation or recycled back to the plasma...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2004
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.00840.x